The first Federal Census for Greene County was taken in 1800, four years after its formation when it was cut off from Washington County. This census included Free Persons of Color in their own households and the number of Free and Enslaved individuals living in white households.
Free Persons of Color in their own household
| Free Head | Other Free | Township | Notes |
| Nasa McCurdy | 2 | Cumberland | |
| Jacob Adams | 11 | Franklin | |
| Richard Starling | 1 | Greene | AKA Richard Sterling |
| William Westbrook | 3 | Greene | |
| James Alford | 1 | Whiteley | |
| Simon Fisher | 5 | Whiteley |
White Household with Enslaved and Free Individuals
| Name | Number of Other Free | Number of Enslaved | Township |
| Charles Swan | 1 | Cumberland | |
| James Hughes | 1 | Cumberland | |
| John Swan | 5 | 5 | Cumberland |
| William Seaton | 1 | Cumberland | |
| Jay Thompson | 5 | 1 | Cumberland |
| James Seaton | 1 | Cumberland | |
| Stephen Gapen | 1 | Dunkard | |
| Theopolis Minor | 1 | Dunkard | |
| Henry Stephens | 1 | Dunkard | |
| John Boreman | 1 | Franklin | |
| William Hudson | 2 | 1 | Greene |
| Samuel Hyde | 1 | Greene | |
| William Minor | 3 | 1 | Greene |
| John Minor | 1 | Greene | |
| Obadiah Minor | 1 | Greene | |
| Thomas Hughes | 3 | Jefferson | |
| James Hook | 3 | Morgan | |
| William Lee | 1 | Morgan | |
| John Ross, Senr | 1 | Morgan |
African American History of Greene County, Pennsylvania 